Intriguingly RSK was also found to phosphorylate CDC25C in Xenopus oocytes 63 suggesting that RSK may also contribute to a G 2 M cell cycle arrest under certain circumstances. Upon DNA damage CDC25 is inhibited by the Chk1 and Chk2 protein kinases and MK2 appears to work in parallel to these enzymes to promote the G 2 M checkpoint in response to stress.
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